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Integrating the Growing Role of the Dentist into the Medical Treatment Team for Sleep Disorders

The Sleep Education Consortium is present the Sleep Education Consortium Conference: Integrating the Growing Role of the Dentist into the Medical Treatment Team for Sleep Disorders.

This conference architects the growing link between dentistry and sleep medicine, and it will become clear how the dentist can play a larger role in the overall health of patients.

In an effort to provide the best educational experience the conference provides lectures specifically designed to address the educational needs of the DDS., and the second day of lectures is open to all health care professionals and has a broader range of sleep related lecture topics.

By addressing the patients’ questions regarding sleep issues, the dentist and support staff can be grounded in the broader aspect of sleep disorders on a basic level. The conference will allow the dentist and support staff to become familiar with a multitude of sleep problems, and they can be more responsive to questions patients may ask as the dentist screens for sleep disorders within their practice. The educational methods will include lectures, Q&A, and panel discussion.

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Burnout: Sleepless Firefighters at Risk of Exhaustion and Mental Health Conditions

Sleep disturbances and mental health challenges are putting close to half of America’s firefighters at high risk of emotional fatigue and exhaustion, new research shows.

The research was conducted by Monash University in Australia in collaboration with Brigham and Women’s Hospital in Boston.

Of the 6,307 firefighters from 66 fire departments across the USA that took part in this cross-sectional study, 49% exhibited high levels of physical and emotional burnout in at least one area.

Firefighters who screened positive for a sleep disorder, in particular insomnia, reported a threefold increased risk of emotional exhaustion. Those with a self-reported diagnosis of post-traumatic stress disorder (PTSD), depression or anxiety had up to four-times the increased risk of burnout.

Sleepiness and short sleep, even in firefighters who did not screen positive for a sleep disorder, were also associated with high levels of burnout.

The collaboration was led by Alexander Wolkow, post-doctoral research fellow and Professor Shantha Rajaratnam in the Turner Institute for Brain and Mental Health at Monash University, and Laura Barger and Charles Czeisler in the Division of Sleep and Circadian Disorders at Brigham and Women’s Hospital.

Researchers investigated whether sleep disorder risk and mental health outcomes in firefighters were associated with burnout, particularly emotional exhaustion, and examined the role of sleep at work in these relationships.

The study identifies the physical and emotional impact that sleep loss and exhaustion can have on firefighters’ ability respond to infernos and other incidents where lives and property are in danger. The study was published online in the Journal of Sleep Research.

“Firefighters are frequently exposed to sleep restriction due to their work schedules, which typically involve 24-hour shifts. These schedules may prevent firefighters from obtaining sufficient sleep in order to feel rested,” Wolkow said.

“Inadequate sleep during and after work, and into rest periods, may impair firefighters’ ability to recover from occupational demands, potentially explaining the heightened burnout risk.”

Almost half of the firefighters surveyed reported having less than six hours of sleep in a 24-hour period when working overnight (between 10 pm and 8 am), including 24-hour shifts, and 31% reported short sleep patterns the day after overnight work or a 24-hour shift.

In an important step forward, researchers provide evidence that short sleep during an overnight shift mediates the link between sleep disorder risk and high burnout on emotional exhaustion and depersonalization levels.

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Inclined Sleeper Infant Deaths Rise to 50 as Industry Continues to Sell the Products

At least 50 babies are now known to have died in infant inclined sleep products such as the Fisher-Price Rock ’n Play Sleeper, raising the death toll from the previous count of 37, according to a Consumer Reports investigation.

Though Fisher-Price and Kids II have recalled their inclined sleepers, several other manufacturers continue to sell similar products that pose the same risks.

Infant inclined sleepers are designed to have babies sleep at an incline between 10 degrees and 30 degrees. All such products increase the likelihood of airway compression and suffocation, according to the American Academy of Pediatrics. And all run counter to recommendations from the AAP, the National Institutes of Health, the Centers for Disease Control and Prevention, and the federal Maternal and Child Health Bureau. These organizations say babies should be put to bed on their back—alone, unrestrained, and on a firm, flat surface free of bumpers and other soft bedding.

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The best anti-aging supplements contain these 5 ingredients

If only we could derive everything we need from the sea, from the refreshing waves and the cooling, salty breeze. If only soaking up the sun could reverse the signs of aging, rather than causing them. If only eating healthy could give our bodies complete nutrition. What can be done? Read more to learn why the Best Anti-Aging Supplements Contain These 5 Ingredients

Did you know that boosting your natural production of vitamin D through exposure to sunlight alone may still not be enough leaving you vitamin-D-deficient? And, while you can intake most of your nutritional needs through a balanced diet, there are just some vitamins and minerals that are too hard to get enough of through diet alone. That’s where anti-aging supplements come in. The best anti-aging supplements work with your body to help you produce youthful radiance on your own.

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As we age, our bodies become less capable of producing and absorbing the anti-aging nutrients we need without supplementary help.

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Best Anti-Aging Supplements Contain Vitamins A, C, D, and E

It should go without saying that the best anti-aging supplements contain vitamins. But what’s important to keep in mind is that the vitamins they contain should be targeted to specific causes of aging. Just throwing a slew of powerful antioxidants at a problem won’t necessarily keep your skin glowing and your hair thick and full. It’s about finding the right balance of each kind of anti-aging vitamin.

When you’re searching the internet and the shelves, be on the lookout for these crucial vitamins in your anti-aging supplements—and be aware of what they can do for you.

Vitamin A

What is the anti-aging ingredient?

In essence, vitamin A is a fat-soluble vitamin that’s extremely instrumental in helping the body carry out several functions, from helping support healthy skin and vision to helping combat free radicals as an essential antioxidant.

What does it do at the cellular level?

Because vitamin A is generally found in three active forms (retinal, retinol, and retinoic acid), it can serve several different functions within the cell, and ultimately, within the body as a whole. Retinol and retinoic acid, specifically, work to help target and alter gene activation and repression.

In other words, vitamin A, in the proper doses, can help to fend off DNA damage and help to keep telomeres from prematurely shortening.

How is it anti-aging?

Vitamin A, as an essential vitamin and powerful antioxidant, helps to maintain the integrity of your cells as you age. It’s anti-aging in that it helps to keep your mucous lining barriers healthy and intact. Furthermore, it helps to generate healthy hair, combat fatigue, and keep your eyes sharper longer.

Vitamin C

What is the anti-aging ingredient?

Vitamin C, unlike vitamin A, isn’t fat-soluble. It’s a water-soluble vitamin that also acts as an antioxidant which helps to fight against free radical damage throughout the body.

What does it do at the cellular level?

As an antioxidant, vitamin C neutralizes free radicals, and in that way, it helps to prevent oxidative damage, which is one of the nine leading causes of aging at the cellular level. Vitamin C is one of the most effective antioxidants at combating free radicals and free radical damage.

How is it anti-aging?

Vitamin C helps in the stimulation of collagen production, and as you may or may not know, collagen production is vital for helping maintain healthy, ageless skin as well as youthful ligaments, cartilage, vertebral discs, joint linings, capillary walls, teeth, and bones. Additionally, vitamin C aids in healthy, youthful metabolism and therefore it can help in maintaining an ideal weight.

Vitamin D

What is the anti-aging ingredient?

Vitamin D is another naturally occurring, fat-soluble vitamin that’s essential for your body’s optimal functioning on several levels.

What does it do at the cellular level?

At the cellular level, vitamin D helps to modulate the genes that encode vital proteins. Many of those proteins help to regulate cell proliferations, differentiation, and apoptosis. To put it simply, vitamin D may aid in the maintenance of cells and may help slow down cell death (apoptosis).

How is it anti-aging?

Because it aids in the slowing down of cell death, vitamin D provides several anti-aging benefits from improved neuromuscular functioning to brighter, more youthful skin and so much more. The best anti-aging supplements, such as Lumity, contain at least 100% of the daily value of vitamin D. Lumity contains 600 IU, which is roughly 150% of the DV.

Vitamin E

What is the anti-aging ingredient?

Vitamin E is a fat-soluble vitamin that acts as a powerful antioxidant. In its most common form, it is a tocopherol, which has been shown to aid in hormone regulation in many instances.

What does it do at the cellular level?

As an antioxidant, vitamin E helps to prevent the oxidation of lipids within your cells. Vitamin E also helps to protect fatty acids in the body while it helps maintain the integrity of some of the hormones being released by the pituitary and adrenal glands.

How is it anti-aging?

In helping to keep your cells and your hormones from oxidizing, vitamin E assists in healing skin, regulating healthy blood pressure, and maintaining cognitive sharpness.

The Best Anti-Aging Supplements Contain Omega-3 Fatty Acids

Most anti-aging supplements can be fairly harsh on the stomach. Many require that you take their supplements with food to mitigate the risk of damage to your stomach’s lining. Not Lumity. Lumity contains ideally proportioned anti-aging ingredients suspended via centrifuge in flaxseed oil. Tablets and hard capsules need to be emulsified in your stomach before they can be absorbed; whereas, the Lumity anti-aging soft gel already contains emulsified ingredients, which means that you don’t have to take Lumity with food, and the powerful antioxidants and other ingredients have the chance to absorb more quickly into your systems. As an added bonus, the flaxseed oil in Lumity is 68% alpha-linolenic acid, which is an omega-3 fatty acid that helps to protect healthy cellular membranes.

Flaxseed Oil

What is the anti-aging ingredient?

As we just mentioned, flaxseed oil is a wonderful source of vital omega-3 fatty acids. The best anti-aging supplements contain some dosage of omega-3 fatty acids, and flaxseed oil is a rich source.

What does it do at the cellular level?

Flaxseed oil and the omega-3 fatty acids within it can help to guard cells against damage. In some cases, omega-3 acids can also help to protect against the damage inflicted by naturally occurring inflammatory responses within the body.

How is it anti-aging?

Flaxseed oil helps to protect and repair skin from the inside out. It can also be particularly instrumental in helping to combat photoaging and sun damage caused by exposure to UVA/UVB radiation. While it won’t erase fine lines or wrinkles, it can help to reduce the appearance of photoaging.

The Best Anti-Aging Supplements Contain Anti-Aging Minerals

The best anti-aging supplements don’t just contain vitamins and omega-3 fatty acids; they also contain anti-aging minerals that help your body to help itself. Though you can derive many vital anti-aging minerals from eating a balanced diet and maintaining proper nutrition habits, it’s almost impossible to get everything you need from diet alone. That’s where the best anti-aging supplements come in. They contain perfectly proportioned vitamins and minerals to help supplement your diet and keep you looking and feeling your absolute best.

Magnesium

What is the anti-aging ingredient?

Magnesium is widely considered an anti-stress mineral. It’s a vital mineral for several functions within the body. From fortifying bones and teeth to promoting healthy muscles and nerves, there are few aspects of the body that magnesium doesn’t help to improve.

What does it do at the cellular level?

At the cellular level, magnesium assists in energy production within the mitochondria, which are the powerhouses of the cell.

How is it anti-aging?

That energy production assistance is essential for youthful energy levels, not just within the cell, but throughout the body. When your body has sufficient magnesium stores, you’re better able to fend off feelings of fatigue, nervousness, and general tiredness.

Selenium

What is the anti-aging ingredient?

Selenium is an anti-aging mineral that helps to boost antioxidant activity within the body, and in doing so, it helps to prevent lipid oxidation from denigrating the integrity of cell membranes.

What does it do at the cellular level?

Comprising more than twenty selenoproteins, selenium helps in the healthy regulation of DNA synthesis and thyroid hormone metabolism. Selenium also contributes to the proper functioning of various antioxidants which help to guard against free radical damage.

How is it anti-aging?

Among the various ways it helps to protect the body against the signs and effects of aging, selenium plays a significant role in helping to maintain healthy, youthful skin, hair, and nails. As we age, our body naturally loses its ability to absorb the proper amount of selenium. In that case, it’s important to have just the right dosage in order to reap all of the positive anti-aging benefits.

Iodine

What is the anti-aging ingredient?

Iodine is a trace element that has antibacterial qualities and has the distinct ability to help protect against the harmful effects of toxic radiation.

What does it do at the cellular level?

Iodine helps to boost the basic functioning of the thyroid gland, which in turn, helps to regulate almost every other system within the body. It also has the ability to help increase the activity of certain antioxidants to aid in the prevention of free radical damage.

How is it anti-aging?

An iodine deficiency can lead to several maladies, including hair loss and high blood pressure. Having enough iodine in your system can help to regulate hormones and thereby help in the formation of healthy skin, hair, and nails. In some cases, it’s been shown to increase hair growth and follicle strength, making your hair thicker, fuller, and healthier overall.

Zinc

What is the anti-aging ingredient?

Zinc is a water-soluble mineral that’s vital and thought to be involved in more bodily functions than any other mineral.

What does it do at the cellular level?

At the cellular level, zinc helps with DNA synthesis and cell replication. Zinc has also been shown to be instrumental in helping to regulate the functioning of white blood cells.

How is it anti-aging?

Because it plays a role in muscle repair and the mitigation of free radical damage, zinc operates on several different levels in an effort to combat the signs and effects of aging. Zinc helps to keep hair, skin, and nails looking and feeling younger. It has also been shown to help in some cases of vision-related conditions, such as night blindness.

The Best Anti-Aging Supplements Contain Vita Complexes

The best anti-aging supplements address the two distinct cycles that your body goes through: sleeping and waking. In the morning, the essential vita complexes in Lumity help to jog your natural energy production throughout the day. The three mocha-colored soft gels that you take each morning don’t rely on stimulants to get your day going. They tap into your body’s natural responses and processes to help ensure that the energy you experience is longer lasting and naturally healthy.

CoQ10

What is the anti-aging ingredient?

Coenzyme q10, also known as CoQ10, is an antioxidant that is naturally present in the body, but it decreases as we age. The best anti-aging supplements contain some measure of CoQ10 in order to aid in energy production—among other anti-aging benefits.

What does it do at the cellular level?

CoQ10 functions as an antioxidant at the cellular level, and as such, it’s effective at helping to protect various components of the cell—including the mitochondria—from oxidative stress. CoQ10 is present in almost every cell in the body, but some cells have a higher concentration of the enzyme because they have greater natural energy needs.

How is it anti-aging?

Coenzyme q10 is a vital nutrient produced within your body that naturally declines over time. In helping to replenish those stores, taking anti-aging supplements with CoQ10 in them further helps to boost more youthful energy and vitality levels.

Turmeric

What is the anti-aging ingredient?

Turmeric is a unique ingredient in the best anti-aging supplements. It’s a spice whose anti-aging benefits have been touted for centuries in India. Turmeric possesses antibacterial properties and is also a powerful antioxidant.

What does it do at the cellular level?

The primary component of turmeric, curcumin, helps to combat bacteria as well as free radicals. Additionally, it has been shown in some instances to boost levels of certain hormones that can help combat various degenerative diseases.

How is it anti-aging?

The curcumin found in turmeric may be helpful in combating certain ailments associated with aging, such as high cholesterol.

Acetyl-l-carnitine

What is the anti-aging ingredient?

Acetyl-l-carnitine is an essential amino acid that not only aids in the production of natural energy, but has also been shown to be instrumental in regulating blood sugar and insulin production.

What does it do at the cellular level?

On the cellular level, acetyl-l-carnitine, sometimes known as carnitine, helps to deliver the necessary fuel into the mitochondria of the cells. That process helps to ignite and drive further energy production within the cell, which may lead to a number of different energizing processes throughout the body.

How is it anti-aging?

Acetyl-l-carnitine has exhibited various anti-aging benefits that range from aiding in healthy muscle retention to improving bone density and healthy liver function. Because it helps to eliminate cellular debris—a major cause of aging—carnitine helps boost energy levels and helps to keep you feeling and looking younger from the inside out.

The Best Anti-Aging Supplements Contain Renew Complexes

Just as the vita complex in Lumity supports natural energy throughout the day, the renew complex in the night-time softgels help to engage the body’s natural tendency to renew, replenish, and regenerate cells and tissues overnight. The best anti-aging supplements contain anti-aging ingredients that aid in the regenerative processes that naturally occur while we sleep. The ultimate goal of the renew complex is to wake rested, rejuvenated, and ready to face the day’s challenges.

Lysine

What is the anti-aging ingredient?

Lysine is an amino acid that serves as a necessary building block for many of the body’s most essential proteins. Lysine is not naturally produced within the body, but it’s necessary for healthy functioning. It can only be derived from a balanced diet or dietary supplements. Not all anti-aging supplements contain lysine; only the best anti-aging supplements think to include this vital nutrient.

What does it do at the cellular level?

As an essential amino acid, lysine helps to build necessary proteins, and it also helps in collagen production and elastin production in the skin to improve the appearance of fine lines and wrinkles and lend an overall more youthful glow.

How is it anti-aging?

Lysine might just be one of the most vital nutrients for helping to combat the external and internal signs of aging. Lysine has been shown to aid in the production of human growth hormone (HGH) overnight, and it’s also been beneficial in helping to support healthy hair growth, youthful skin, and rejuvenated muscles.

Alanine

What is the anti-aging ingredient?

Alanine, unlike many of the other amino acids found in Lumity, is actually a non-essential amino acid. That doesn’t mean that it’s not necessary for the healthy functioning of your body’s system; it simply means that it can be naturally synthesized within your body. Even though it can be produced without supplementation, supplementing your diet with the best anti-aging supplements that contain alanine may have a positive anti-aging effect.

What does it do at the cellular level?

At the cellular level, alanine helps to interfere with the glycation process, which is another major cause of aging. Glycation naturally damages collagen, so because alanine helps to combat glycation, it plays a part in stimulating natural collagen production, which can help reduce the appearance of photoaging (fewer wrinkles, fine lines, and age spots).

How is it anti-aging?

Alanine not only helps boost collagen production, thereby softening the appearance of fine lines, wrinkles, age spots, and sagging skin, but it also aids in healthy muscle regeneration and can have a positive anti-aging effect on fatigue, sugar metabolism, and tiredness.

Glutamine

What is the anti-aging ingredient?

Another non-essential amino acid, glutamine has the ability to contribute to the production of other amino acids. Glutamine may also contribute to the stimulation of human growth hormone (HGH).

What does it do at the cellular level?

Glutamine is necessary for the epithelial cells that line the small intestine as well as for other cells that handle immunity. It serves as the metabolic fuel for those cells to carry out their important functions in the body.

How is it anti-aging?

During periods of stress, the body typically requires higher levels of glutamine. As we age, our glutamine levels naturally decline. As such, it’s incredibly important to restore the body’s youthful level of glutamine in order to maintain proper muscle functioning, liver health, and stable blood glucose.

Arginine

What is the anti-aging ingredient?

Arginine is yet another amino acid that aids in the synthesis of proteins. Arginine is a naturally occurring substance in the body that diminishes in production over time. With supplemental help, youthful levels of arginine may be restored.

What does it do at the cellular level?

At the cellular level, arginine assists in healthy cellular division, helping to ensure that the cells divide properly and don’t fall prey to apoptosis (cell death) prematurely.

How is it anti-aging?

One of the primary ways that arginine helps to slow down the aging process is by aiding in human growth hormone (HGH) production. When anti-aging supplements containing arginine are taken before bedtime, they help to stimulate the naturally rejuvenating hormone that has been shown to increase muscle mass, the ability to burn fat, and bone density. It may also help to increase the elasticity of mature skin and reduce the appearance of wrinkles, fine lines, and age spots.

L-cysteine

What is the anti-aging ingredient?

L-cysteine is an amino acid that’s an essential component to the best anti-aging supplements on the market, including Lumity.

What does it do at the cellular level?

As a sulfur-containing amino acid that boosts intracellular levels of the antioxidant glutathione, l-cysteine helps restore your cells’ ability to fight off oxidative damage. It also contributes to the protection against DNA damage.

How is it anti-aging?

L-cysteine is a powerful antioxidant, which means that it has the ability to help ward off harmful free radical damage. In warding off that damage, l-cysteine helps stimulate and maintain healthy collagen production, which may mean smoother skin that’s naturally more radiant and glowing.

At the end of the day, the best anti-aging supplements are those that work with your body to help slow down aging from the inside out. Premium anti-aging supplements like Lumity help provide just what your body needs and nothing that it doesn’t in order to regain your youthful glow and natural radiance.

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All day. All night. All natural. Feel alive with Lumity.

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The Goal of Kidney Rejuvenation

The authors of this open access paper review the aging of the kidney and consider the prospects for using factors from young blood as a means of rejuvenation. This is a fairly narrow view, as there are many other approaches that should produce rejuvenation of the aged kidney, ranging from those close to realization, such as senolytic therapies to clear senescent cells, or various approaches to stem cell therapy, to those yet to be achieved, meaning much of the rest of the SENS agenda of rejuvenation biotechnologies to repair the damage that causes aging. Nonetheless, after so many years of trying to persuade the research community to open up on the topic of addressing the mechanisms of aging as a means of therapy, it is very pleasant to see so many publications in the literature doing just that. The present open discourse is a sea change in comparison to the silence of a decade or two ago, in which few researchers were willing to speak in public about treating aging. The science was always valid and promising, it is the culture that has changed for the better.


It is well established that aging is associated with structural and functional renal changes. With the possible exception of the lung, the changes in kidney function with normal aging are the most dramatic of any human organ or organ system. The normal kidney loses about 25% of its mass during aging, with the loss involving both cortical glomeruli and tubules. Functionally, the aging kidney has a parallel decline in both glomerular and tubular function. The Baltimore longitudinal study demonstrated an average of 0.75 mL/min/year decline in glomerular filtration rate (GFR) in 254 men without hypertension or kidney disease. The GFR loss rate is tripled in subjects over 40 as compared with those under 40.

Cellular senescence describes an everlasting growth arrest of still viable and metabolically active cells. The cell-cycle regulators and tumor suppressors p16Ink4a and p19ARF are involved in cellular senescence. The expression of p16 Ink4a in the kidney has been known to increase with age and could be found in a variety of renal cell types. Renal p16Ink4a expression has been suggested as an ideal marker for renal aging and shown to foresee transplant outcome. In normal human glomerular, p16Ink4a expression is increased with age and in all resident cell types. Studies in a transgenic mouse model confirmed that ablating p16Ink4a positive senescent cells not only prolongs the lifespan, but also attenuates glomerulosclerosis in aging kidney and decreasse blood urea nitrogen levels. Furthermore, depletion of p16Ink4a resulted in reduction of renal interstitial fibrosis and nephron atrophy in mice after ischemia-reperfusion injury, indicating inhibition of senescence provides a protective effect on the development of fibrosis.

Considering the increase of the aging population, it is extremely urgent to identify a way to retard the aging process or rejuvenate the community. To test the effects of young blood on aged organ, young blood infusion or parabiosis may be used. Parabiosis is an experimental model aiming to join the circulatory system of two animals. Heterochronic parabiosis is used to connect an aged partner to a young partner, and can be used to demonstrate the effects of young blood on aged organs, and vice versa. With this model, rejuvenation in the aged heterochronic parabiont has been shown in different organs such as muscle, liver, brain, and heart.

In aged kidneys, a recent study showed that young blood environment enhances the autophagy of aged kidney through down-regulation of aging-related protein p16Ink4a and SA-β-gal, up-regulation of autophagy factors Atg5 and LC3BII, and down-regulation of autophagic degradation protein p62. Moreover, recent studies provided evidence that young systemic milieu may alleviate renal ischemia-reperfusion injury in elderly mice probably through reduction of oxidative stress, inflammation, apoptosis, and enhancement of autophagy in the injured aged kidney. Although evidence showed that young blood can attenuate renal aging and injury induced by ischemia-reperfusion injury in elderly mice, it will be important to identify and study the effects of specific blood-borne rejuvenating factors in the young blood or aging factors in the old blood in addition to put efforts into delineate the mechanisms underlying the renal cell senescence. This information will provide novel ideas to turn back the clock of the aging kidneys.

Link: https://doi.org/10.1016/j.jfma.2019.05.020